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KMID : 0368820040430030277
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Journal of the Korean Neuropsychiatr Association
2004 Volume.43 No. 3 p.277 ~ p.282
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Polymorphisms of TAP2 Gene in Schizophrenia
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Abstract
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Objectives : The genes for transporters associated with antigen processing (TAP) are located near to HLA class II coding regions and related to antigen presentation. Therefore polymorphisms of TAP might alter the T-cell mediated immune response and influence susceptibility to schizophrenia, which is known to have alterations in T-cell immunity. The aim of this study was to verify the relationship between schizophrenia and polymorphisms of TAP2 genes.
Methods : 257 patients with schizophrenia and 184 normal controls participated in this study. TAP2 polymorphic residues at positions 379, 565 and 665 were typed using amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) and single-strand conformation polymorphism (SSCP). The resulted products, TAP2379 TAP2565 and TAP265 were assessed.
Results : The frequency of TAP2 alleles did not differ between patients with schizophrenia and controls. The polymorphic sites TAP2379 TAP2565 and TAP2665 did not show any difference in their amino acid substitution frequencies.
Conclusion : This study did not show the association of the TAP2 gene with schizophrenia in Korean population. Further studies are needed to test the informative value of haplotypes including other polymorphic sites. (J Korean Neuropsychiatr Assoc 2004;43(3):277-282)
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